Drug resistance mechanisms and drug susceptibility testing for tuberculosis
نویسندگان
چکیده
منابع مشابه
Drug Resistance in Mycobacterium tuberculosis: Molecular Mechanisms and Laboratory Susceptibility Testing
Evidence is accumulating that drug resistance in Mycobacterium tuberculosis is by no means a homogeneous biological entity. This perception implies limitations of current procedures for in vitro drug susceptibility testing, based on unique but often poorly understood techniques in diagnostic mycobacteriology. The aim of this paper is to briefly review the molecular mechanisms of mycobacterial d...
متن کاملDrug-resistance mechanisms and tuberculosis drugs.
Department of Medicine, Addenbrooke’s Hospital, University of Cambridge, Cambridge CB2 0QW, UK (CUK, BJ, SJP, MET); School of Medicine, Tsinghua University, Beijing, China (BJ); Faculty of Law, University of Cambridge, Cambridge, UK (KL); Clinical Microbiology and Public Health Laboratory, Public Health England, Cambridge, UK (MJE, NMB, SJP, MET); Molecular Mycobacteriology, Research Center Bor...
متن کاملPerformance of the microscopic observation drug susceptibility assay in drug susceptibility testing for Mycobacterium tuberculosis.
The drug susceptibility testing performance of a broth-based method with microscopic reading of bacillary growth, the microscopic observation drug susceptibility (MODS) assay, was compared to that of the reference 7H10 agar method of proportion by using 53 isolates of Mycobacterium tuberculosis from persons at risk for multidrug-resistant TB. For isoniazid (0.1 micro g/ml) and rifampin (2.0 mic...
متن کاملTargeting Drug Resistance Mechanisms in Mycobacterium tuberculosis
Historically, tuberculosis (TB) has left a scar as mankind’s greatest infectious killer. With evidence of TB infection dating back nine millenia to a Neolithic Eastern Mediterranean settlement [1], this ancient disease meant almost certain death to those infected, a phenomenon spanning pre-antibiotic eras from the time of the Roman empire all the way to the beginning of the 20th century. But wi...
متن کاملDrug Resistance Mechanisms in Mycobacterium tuberculosis.
Tuberculosis (TB) is a serious public health problem worldwide. Its situation is worsened by the presence of multidrug resistant (MDR) strains of Mycobacterium tuberculosis, the causative agent of the disease. In recent years, even more serious forms of drug resistance have been reported. A better knowledge of the mechanisms of drug resistance of M. tuberculosis and the relevant molecular mecha...
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ژورنال
عنوان ژورنال: Respirology
سال: 2018
ISSN: 1323-7799,1440-1843
DOI: 10.1111/resp.13393